There are several brands of Metformin. As it is most prescribed oral antihyperglycemic agent that is used for TypeII Diabetes Mellitus. The objective of this study is to develop the degradation studies of different brands of Metformin HCl 500mg.Metformin brands were subjected to different stress conditions according to ICH guidelines. The amount of degradation product can be calculated by using UV Spectrophotometer. Deionized water was used as solvent. According to specification of IP, the content official limit of not less than (95%) and not more than (105%) of the label amount with the absorbance at 232nm.result is shown in the form of graphical structure. When the brands i.e Glycomet, Glyciphage and Mefomin were treated with different degradation parameters such as acid, heat and UV light it was found that the drug degradation observed in all three brands of Metformin while no degradation is observed when these three brands were treated with 0.1N NaOH.