According to the official World Health Organization (WHO) data, India tops the list of countries with the highest number of diabetics. In 2014, 8.5% of adults aged 18 years and older had diabetes. In 2015, diabetes was the direct cause of 1.6 million deaths. Diabetes, particularly type 2 is associated with various cardiovascular diseases and it is the major cause of non-traumatic blindness and renal failure. Nowadays, there are a lot of options available to treat type 2 diabetes with the help of various anti-hyperglycemic medications, such as sulfonylureas, metformin etc. Although, these drugs have ability to reduce blood sugar level but has many adverse effects. On the other hand, Ayurveda, a science of life, has ability to treat Diabetes in holistic way. In Ayurveda, Diabetes Mellitus can be correlated with “Madhumeha” which is one of the vatic types of Prameha caused by vitiation of Vata due to Avarana of Pitta and Kapha. Ayurvedic approach to DM Type 2 management can provide a better option in preventing disease without causing any side effects. Panchakarma is a unique approach of Ayurveda which helps in revitalizing tissues, removing the root cause of disease. Virechana is the second procedure in the sequence of Panchakarma, mainly aimed at removing Pitta Dosha along with other doshas. Virechana stimulates liver which is the source of all metabolic functions of the body. So it can be hypothesized that in the early stage of insulin resistance or decreased insulin secretion, it can have drastic positive effects in the patients of DM Type 2.