The objective of this study is to analysed force degradation studies by treating the different brands of Paracetamol under hydrolytic (acidic and basic), photolytic nd thermal stress condition by using spectrophotometer, as define under International Conference on Harmonisation guidelineQ1A(R2). According to specification of United state of pharmacopoeia, the content official limit of not less than (98%) and not more than (110%) the label amount. Our hypothesis was that when all the brands of paracetamol (pacimol, febrex and pyrigesic) where exposed to different degradation parameters. The result of study conclude that when different brand of paracetamol where treated with 0.1N HCl and 0.1N NaOH degradation was observe in all the three brands. Whereas when the three brands were expose to ultraviolet light slight degradation where observed while no degradation is observe when expose to heat.