Diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose. Metformin hydrochloride is an anti-diabetic drug from the bigunaide class of oral antihyperglycemic agents.Half-life 6.2 hours. Duration of action is 8-12 hours. Metformin decreases blood glucose levels by decreasing hepatic glucose production, decreasing intestinal absorption of glucose. metformin hydrochloride and gliclazide were prepared by using different concentration of polymers of various grades of HPMC, Carboxy methyl cellulose, Calcium phosphate dibasic anhydrous, Micro crystalline cellulose, PVP, Lactose monohydrate. Different types of pellets i.e. Metformin pellets, coated Metformin pellets and disintegrate pellets were shown independent influence on the formulation. In order to evaluate the pHs effect on the transdermal drug delivery, HPMC/PVA based TDS-patch was prepared. Floating tablet Metformin HCl have been shown sustained release there by proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration.