Anybody can submit their Paper on [email protected]

Downloads

Copyright Form Paper Format

Open Access

open access

search paper

Google Scholar

Abstract

1.  DYSREGULATED OSTEOPROTEGERIN/ RECEPTOR-ACTIVATOR OF NUCLEAR FACTOR-κB LIGAND METABOLISM AND BIOCHEMICAL MARKERS OF BONE TOURNOVER IN ADVANCED CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Kochetkova, E.A, Ugai, L.G, Nevzorova, V.A, Maistrovskaia Yu.V, Geltser B.I.
Pathogenesis of osteoporosis in advanced stages chronic obstructive pulmonary disease (COPD) is unclear. Therefore, the study of OPG-RANK-RANKL axis contribution to pathogenesis of osteopenic syndrome in COPD is of particular interest. Aim: to estimate the relationships between serum OPG, RANKL, TNF-α and bone metabolism markers levels, bone mineral density (BMD) in advanced stages COPD. Methods: pulmonary function, BMD at the lumbar spine and femoral neck, serum OPG, RANKL, TNF-α and its receptors (sTNFR I, sTNFR II), osteocalcin (bone formation marker), and βCrossLaps (marker of bone resorption) levels were measured in 67 patients with severe and very severe stages COPD and 82 healthy. Results: 61% COPD patients have osteoporosis and BMD were normal in 12% subjects. Osteopenic syndrome (osteopenia and osteoporosis) was determinated in 44% control individuals. Serum βCrossLaps, TNF-α and its receptors, RANKL levels were significant higher and osteocalcin, OPG concentrations were lower in patients with COPD than in control. The univariate analysis showed that OPG correlated with FEV1 (r=0,63, p<0,001), osteocalcin (r=0,57, p<0,01), both lumbar and femur neck BMD (lumbar: r=0,43, p<0,05 and femur neck: r=0,64, p<0,001), pCO2 (r=-0,39, p<0,05), RANKL (r=-0,67, p<0,001), TNF-a (r=-0,046, p<0,05), and its receptors (sTNFR-I: r=-0,41, p<0,05 and sTNFR-II: r=-0,37, p<0,05). In contrast, we established the inverse relationship between serum RANKL and BMD both at the lumbar spine and at the femur neck (r=-0,48, p<0,01 and r=-0,59, p<0,00 1 respectively); and also direct correlation with βCrossLaps (r=0,42, p<0,05). There were no relationships between serum RANKL levels and pulmonary lung parameters, TNF-α and its receptors. Conclusion: our results suggest that serum OPG and RANKL levels participate in the pathogenesis of respiratory failure and loss of bone density in patients with advanced stages COPD

IC Value

Terna Conference

If your Paper is Non-Technical Click here

ijahs-logo

Conference Lists


Notice Board

* Author will received there Hard Copy Certificates by 15th of Sept.

* International Conference on jan 2015 organized by GRDS and IJTRA Conference papers are published, authors can check there paper in special issue.

* Next date of Publication is 1st October2015.

* Flash drive and DVDs are also available of volume 2 (Proceeding).
Evaluation Report

Research & Devlopment Wing

Quality Evaluation

Proceeding

  • ijtra_proceeding
  • ijtra_proceeding
  • ijtra_proceeding
  • ijtra_proceeding
  • ijtra_proceeding
  • ijtra_proceeding
ijtra_proceeding1 ijtra_proceeding2 3
Slider Website by WOWSlider.com v4.7

Total visitors

Frequency

frequnecy

Online Users
Your Browser: Unknown Browser
Your Operating System: Unknown OS Platform