Abstract
This study was designed to evaluate the effect of 70% ethanolic crude extract of Portulaca oleracea L on mice orgons . (In vivo),In vivo, the acute toxicity of 70 % ethanolic extract of the plant on normal mice was studied. No toxic effect was noted on normal mice even at 9500 mg /kg B.W S/C injection.Histopathological changes due to ethanolic extract of the plant in healthy mice were summarized in hyperplasia of white pulp with amyloid deposition, proliferation of megakaryocytes and mononuclear cell infiltration in the liver and kidney parenchyma. There were no significant lesions detected in the brain, heart and ovary in all treated groups.