Medicinal plant extracts prepared with various selected solvents from four species, Glycyrrhiza glabra, Piper bittle, Azadirachta indica and Moringa olifera, were screened for animicrobial activity by using well diffusion method. Plant extracts showed strong antimicrobial action against microbes, among the plant extracts the extracts of Piper bittle shows maximum antimicrobial activity against all microbes. Moriga extract gave antimicrobial activity only against Staphylococcus aureus while all other strains were resistant to this extract. Escherichia coli was resistant to all extracts except Piper extract.