Cassia sophera (Caesalpiniaceae) has a variety of ethnic medicinal uses along with antioxidant activity. In present study anti-inflammatory activities with alcoholic (AEACS) and aqueous (AQEACS) extracts of aerial part of C. sophera are evaluated. Aerial parts powder successively extracted with alcohol and water was subjected for phytochemical screening to identify different phytoconstituents. LD50 studies for both the extracts were conducted up to the dose level of 2 g/kg following OECD guidelines No. 425. The anti-inflammatory activity was studied in carrageenan and formalin induced paw oedema (acute) models in rats. Phytochemical investigations revealed the presence of carbohydrates, amino acids, fixed oils, fats, glycosides and sterols in AEACS and AQEACS. LD50 studies for alcoholic and aqueous extracts up to maximum of 2g/kg dose level no mortality was observed in any of the animals that indicated their practically nontoxic nature. Both the extracts significantly reduced the paw oedema volume in carrageenan and formalin induced (acute) paw oedema models in rats