The experiments were performed to determine the effect of administering zinc and vitamin E on the gastric mucosa of ethanol-induced ulcerogenic rats. Fourty-two adult rats comprising both sexes served as subjects. They were shared into seven groups I - VII of six rats per group. Drugs were administered orally for seven days. Group I - received distilled water only; Group II - ethanol 5ml/kg; Group III - 100 mg/kg cimetidine + 5 ml/kg ethanol; Group IV - 100 mg/kg vitamin E + 5 ml/kg ethanol; Group V – 50 mg/kg zinc gluconate + 5 ml/kg ethanol; Group VI - 100 mg/kg vitamin E + 50 mg/kg zinc gluconate + 5 ml/kg ethanol; Group VII - 100 mg/kg vitamin E + 50 mg/kg zinc gluconate only. At the end of the experiment, the animals were sacrificed and their stomachs collected and examined for lesions, the gastric mucus was estimated and their histopathology section analyzed. The results showed that ethanol administration caused significant (P < 0.05) increase in the ulcer index as indicated in group II (11.9 ± 2.83%) while, the groups administered with vitamin E alone (6.0 ± 0.63%) and zinc alone (1.2 ± 0.20%) showed significant (P < 0.05) decrease in the ulcer index and the co-administration of the zinc and vitamin E further decreased the value (0.9 ± 0.11%) although there was no significant difference between the values for zinc alone and the co-administration of zinc and vitamin E. Gastric mucus results showed that there was significant (P < 0.05) difference between groups treated with zinc alone (7.5 ± 0.10 mg dye absorbed/g tissue) and vitamin E (2.7 ± 0.40 mg dye absorbed/g tissue) alone compared to the negative control group (4.0 ± 0.20 mg dye absorbed/g tissue). Thus, it was concluded that zinc and vitamin E ameliorated ethanol induced lesions and the gastric mucus as observed by the percentage index calculated (Zinc- 89.2% and vitamin E- 49.58%) in the ulcerogenic rats.