The past decade has seen a dramatic increase in the number of marine derived products in the market. The sea houses a wide variety of flora and fauna whose extracts have proved to have therapeutic potential in various disorders like cancer, macular degeneration etc. This has prompted researchers to shift their focus from synthetic compounds to these natural products. However, drug development and research is a tedious process. Researchers have to face challenges at every step beginning from procurement to obtaining successful trial results. Moreover, the sea as a source is getting rapidly depleted due to global warming and human activities like tourism and deforestation. In this article we have briefly reviewed some promising marine compounds. Also we have presented a few compounds which are under study and could prove to be a therapeutic boon. This review also outlines the obstacles that need to be overcome for increasing the success rate of marine drugs..