The main purpose of this study was to analyze the relationship between faculty members’ knowledge management and self-efficacy in branches of Islamic Azad University Region 1. Research population included 2181 faculty members and the sample were 436 person which were selected by random stratified cluster based on krejcey Morgan table. Jashpara knowledge management questionnaire (chronbach alpha= 0.89) and shwarzer et al (1991)self-efficacy questionnaire (chronbach alpha=0.82)with appropriate validity based on the specialists points of view were used to conduct this research. Pearson correlation coefficient and stepwise regression tests were used to analyze the relationship between faculty members’ knowledge management and their self-efficacy. the results showed that all dimensions of knowledge management including knowledge creating, organizing, implementing and sharing had a positive and significant relationship with faculty members’ self-efficacy. Among the dimensions of knowledge management , knowledge sharing and knowledge organizing had a significant power for predicting faculty members’ self-efficacy.