Chemotherapy used as drugs alone or a combination plays a major role in the treatment of cancer. The objectives of the study were to develop, implement and evaluate the outcome of a chemotherapy counselling module among oncology patients by pharmacists based on their nausea and vomiting. Methodology: A randomized, single blind, placebo controlled study design was used in this study. A total of 162 patients were randomly selected and allocated into intervention and control groups using a single blind method. Intervention: Counselling module Managing Patients on Chemotherapy along with repetitive counseling for oncology patients undergoing chemotherapy. Outcome: Effectiveness of counseling module Managing Patients on Chemotherapy Pharmacists during baseline, first follow-up post-intervention, second follow-up and third follow-up. Results: Physical effects showed large effect size for nausea (p = 0.001, partial È 2 = 0.434), and vomiting (p = 0.001, partial È 2 = 0.337). Conclusion: In conclusion, the Managing Patients on Chemotherapy by Pharmacists counselling module has been shown to be effective in improving nausea and vomiting side effects among oncology patients undergoing chemotherapy