Background: Labor may be the most painful experience many women ever encounter. pain when unrelieved can have adverse effects on the mother, course of labor as well as on the fetal wellbeing Objective : To find an easy, safe and effective method to control labor pain with minimal intervention, without affecting the course of labor, measured by assessing the degree of maternal satisfaction, obstetrical and neonatal outcome with prevention of complications. Study design: Comparison study Setting: Department of Obstetrics and Gynecology; in corporation with the anesthetic department at Al-Imamain AL-Kadhemain Medical City ; Baghdad, Iraq. from 1st of march 2010 to the 1st of march 2011. Patient and methods: This study include 150pregnant women at term, were divided into 3 groups: control group, group received epidural analgesia, group received intrathecal analgesia. We studied obstetrical and neonatal outcome, side effects and complications. Results: Longer labor time, more operative delivery were in epidural group. shorter labor time, better maternal and neonatal outcome in intrathecal group. Both associated with good pain control. Conclusion: Single-dose ITN is good substitute for EA specially in women in advanced labor, multiparous or women with suspected uncomplicated labor course ; ITA will offer rapid and significant pain relief without affecting the course of labor.