Coronary artery disease(CAD) possess a number of risk factors,hypercholesterolemia and obesity are the main ones. The basic pathology of CAD is the deposition of altered lipid on endothelium. Low density lipoproteins (LDL) are one such altered lipid which is oxidatevely modified. Lipid peroxidation has been estimated by several methods.Malondialdehyde (MDA) is estimated by thiobarbituric acid (TBA) method clinically. In this study of 80 cases of CAD were selected for evaluation. The body mass index (BMI), lipid profile and level of free radicals (MDA)were measured .Thirty four cases (42.5%)were with normal BMI(20-25),40 case (50%) were in the overweight range of BMI (26-30), and only 6 cases(7.5%)were in the obesity group with BMI more than 30. BMI correlated well with the level of total cholesterol(Tc),low density lipoprotein cholesterol (LDL-c) and MDA.BMI did not show any correlation with triglyceride (Tg) or high density lipoprotein cholesterol (HDL-c). MDA level correlated well with Tc,Tg levels and BMI,poorly with LDL-c and inversely with HDL-c.