Benign prostatic hyperplasia (BPH) is the most common condition in ageing men, associated with lower urinary tract symptoms (LUTS). In Ayurveda, Vatashthila disease closely resembles with Benign Prostatic Hyperplasia (BPH) of modern medicine in its signs and symptoms. A clinical trial was conducted in this study group of 30 males diagnosed with symptomatic Benign Prostatic Hyperplasia (Vatashthila). Patients were selected randomly irrespective of their religion, race, occupation etc. They were administered Trikantakadi guggulu, a herbal formulation, at a dose of 2 tablets Bid a day for three months and monitored at every 15 days interval during the study period. The irritative and obstructive symptoms of BPH (Vatashthila) like frequency, urgency, staining, weak stream, incomplete emptying, nocturia, residual urine and uroflow rate were observed over the treatment. Analysis of result showed improvement in BPH (Vatashthila). Finally study concluded that Trikantakadi guggulu is effective for symptomatic relief in Vatashthila (BPH).